Mechanisms of topical delivery of liposomally entrapped drugs
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چکیده
منابع مشابه
Topical delivery of liposomally encapsulated gamma-interferon.
The extent of uptake of gamma interferon (gamma-IFN) in various strata of hairless mouse, human and hamster skin upon application of a liposomal formulation and an aqueous solution were determined by in vitro diffusion cell experiments. For each of the animal species studied, 70-80% of the liposomally entrapped IFN was deposited onto or penetrated into the skin as determined 24 h after in vitro...
متن کاملThe fate in vivo of liposomally entrapped drugs in pregnant rats.
of these two procedures in a new semi-quantitative method for the study of galactotransferase activities. This appears to be the first report of phosphorimetry being used specifically for the measurement of an enzyme activity. Various concentrations (0.051 .O unit/ml) of bovine milk galactotransferase (EC 2.4.22.3; Sigma) were incubated in stoppered tubes with 1.0mI of SOm~-glycine/NaOH buffer,...
متن کاملTopical Delivery System of Liposomally Encapsulated Volatile Oil of Anethum Graveolens
An essential step in the characterization of liposomal systems as drug vectors is one that analyzes the release rate of incorporated substances. In vitro release tests are used not only to characterize various formulations of therapeutic use, but also to predict their in vivo behavior. The objective of this work was to formulate and in vitro characterize hydrogels containing liposomal suspensio...
متن کاملTopical Antiacne Drugs Delivery Systems
Received: August 23, 2016 Revised: September 10, 2016 Accepted: October 03, 2016 Abstract: Background: Acne vulgaris (commonly called acne) is the most prevalent skin complication of different causes with a higher prevalence in adolescents. Topical administration is used as first-choice therapy in mild acne, whereas for moderate and severe acne, systemic administration is required in addition t...
متن کاملThe gastrointestinal absorption of liposomally entrapped insulin in normal rats [proceedings].
The use of liposomes as carriers of therapeutic agents has been extensively reviewed (Tyrrell et al., 1976). We (Patel & Ryman, 1976) have shown that encapsulation within liposomes may be an effective way of administering insulin orally, by which route it is normally destroyed in the gastrointestinal tract. When liposomally entrapped insulin was given orally to diabetic rats, there was a signif...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 1985
ISSN: 0168-3659
DOI: 10.1016/0168-3659(85)90033-1